Phencyclidine (PCP)

17.18

Phencyclidine (PCP) is a dissociative NMDA receptor antagonist primarily used in research on neuropharmacology and psychiatric disorders, known for potent anesthetic and psychotomimetic effects.

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Buy Phencyclidine (PCP) – USA & Europe

1. What is Phencyclidine (PCP)?

Phencyclidine, commonly known as PCP or “Angel Dust,” is a dissociative anesthetic originally developed for surgical anesthesia. It acts primarily as an NMDA receptor antagonist, producing profound dissociative, hallucinogenic, and neuropharmacological effects. Although discontinued in clinical use due to severe side effects, PCP remains a substance of research interest and illicit use.

2. Chemical Composition & Structure

Phencyclidine has the chemical formula C17H25N and a molecular weight of approximately 243.39 g/mol. Its full chemical name is 1-(1-phenylcyclohexyl)piperidine. The structure consists of a piperidine ring bound to a cyclohexyl group with a phenyl substitution. It is a lipophilic solid soluble in water and alcohol.

3. Research Applications

PCP is used in neuropharmacological research to study NMDA receptor function, glutamatergic signaling, and the pathophysiology of schizophrenia and other psychiatric disorders due to its psychotomimetic effects. Its ability to induce dissociation and psychosis-like symptoms underpins models for schizophrenia research.

4. Recommended Laboratory Handling & Safety Guidelines

Use gloves, protective eyewear, and work in a well-ventilated area or fume hood to prevent exposure. Avoid inhalation, ingestion, and skin contact. Store in tightly sealed containers at controlled temperatures to maintain stability.

5. Hazard Warnings & Risk Statements

PCP is classified as a hazardous and controlled substance with potential for abuse and serious adverse psychological effects. Proper hazard communication and safe handling procedures are mandatory.

6. Compatibility with Other Substances

PCP interacts with CNS depressants and other psychoactive agents; co-administration requires careful monitoring.

7. Emergency Protocols for Exposure

In cases of overdose or acute toxicity, immediate supportive care and emergency intervention are critical.

8. Storage Stability & Shelf Life

Store in cool, dry, dark conditions to maintain chemical integrity over long periods.

9. Licensing & Purchase

Highly regulated and controlled; available only for authorized research and clinical uses.

10. Legal Status for Online Purchase

Stringently controlled worldwide; adherence to local laws is imperative.

11. Laboratory Safety Precautions

Use PPE and proper containment to minimize accidental exposure.

12. Special Medical Considerations

Avoid use with cardiovascular, neurological, or psychiatric disorders due to severe risks.

13. Allergic and Sensitization Risks

Low but gloves reduce contact risk.

14. Interactions with Other Chemicals

Potentially dangerous interactions with CNS depressants and stimulants.

15. Pregnancy Precautions

Pregnancy contraindicated.

16. Handling for Experimental Consistency

Accurate dosing, secure storage, and thorough documentation recommended.

17. Optimizing Research Outcomes

Use analytical-grade PCP; monitor purity and stability.

18. Reported Pharmacological Effects

Produces anesthesia, dissociation, hallucinations, neurotoxicity, and psychotomimetic effects.

19. Known Adverse Effects

Include agitation, hallucination, hypertension, convulsions, and neurotoxicity.

20. Severe Exposure Management

Urgent medical assistance is necessary.

21. Solvent Use

Soluble in alcohol and organic solvents; sparingly soluble in water.

22. Research Scheduling

Maintain consistent scheduling to preserve data integrity.

23. Storage Duration Recommendations

Stable with correct storage; degrade with improper conditions.

24. Post-Research Stability

Store in original containers; dispose of degraded material per regulations.

25. Dependency and Sensitization Risks

High abuse potential with risk of psychological dependence.

26. Long-Term Storage

Store under temperature-controlled, dark, dry conditions.

27. Alternative Research Molecules

Ketamine, MK-801 (dizocilpine), and other NMDA antagonists for comparison.

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