Buy Esketamine (S-Ketamine) – USA & Europe

1. What is Esketamine (S-Ketamine)?

Esketamine, also known as S-Ketamine, is the S-enantiomer of racemic ketamine and is a potent NMDA receptor antagonist used in anesthesia and psychiatric treatments. It has been approved as a nasal spray for treatment-resistant major depressive disorder, providing rapid antidepressant effects distinct from traditional therapies.

2. Chemical Composition & Structure

Esketamine has the molecular formula C13H16ClNO and a molar mass of 237.7 g/mol. The molecule is a substituted cyclohexanone derivative with a chlorophenyl and methylamino group. The S-enantiomer is more pharmacologically active than the R-enantiomer, exhibiting greater affinity for NMDA receptors and higher anesthetic potency.

3. Research Applications

Esketamine is researched extensively for its rapid-acting antidepressant properties, analgesia, and anesthesia. Its NMDA receptor antagonism promotes neuroplasticity and modulates glutamatergic neurotransmission, with applications in treatment-resistant depression, PTSD, and chronic pain.

4. Recommended Laboratory Handling & Safety Guidelines

Handle with gloves and eye protection in a well-ventilated area or fume hood. Store in airtight containers, away from light and heat, to preserve stability. Ensure compliance with regulatory and institutional safety requirements.

5. Hazard Warnings & Risk Statements

Controlled substance with potential for abuse and adverse neuropsychological effects. Can cause dissociation, elevated blood pressure, and tachycardia. Use caution and appropriate labeling.

6. Compatibility with Other Substances

Potential interactions with CNS depressants, serotonergic drugs, and other anesthetics; avoid unsupervised polypharmacy in research or clinical use.

7. Emergency Protocols for Exposure

Supportive treatment and emergency medical care are necessary for overdose or severe reactions.

8. Storage Stability & Shelf Life

Stable for years under proper storage: cool, dark, moisture-free conditions.

9. Licensing & Purchase

Available by prescription or research license depending on jurisdiction. Confirm regulatory compliance prior to acquisition.

10. Legal Status for Online Purchase

Highly regulated; verify laws before purchase.

11. Laboratory Safety Measures

Use standard PPE and containment to prevent accidental exposure.

12. Special Medical Considerations

Avoid in psychiatric or cardiovascular vulnerable populations without supervision.

13. Allergenic Potential

Minimal; gloves recommended to prevent skin contact.

14. Interactions with Other Substances

Monitor carefully for interactions with CNS-active agents.

15. Pregnancy Precautions

Contraindicated unless benefits outweigh risks.

16. Handling for Research Consistency

Accurate dosing and documentation essential for reproducibility.

17. Optimizing Research Outcomes

Use pharmaceutical-grade purity and validated assays.

18. Reported Pharmacological Effects

Rapid antidepressant action, anesthesia, analgesia, dissociative effects.

19. Known Adverse Effects

Dissociation, hypertension, agitation, nausea.

20. Severe Exposure Protocol

Emergency care imperative for overdoses.

21. Solvent Use

Water soluble; commonly used as hydrochloride salt.

22. Research Scheduling Importance

Consistent administration optimizes data integrity.

23. Storage Duration Recommendations

Preserve potency by storing properly; typical stability for years.

24. Post-Research Stability

Stability maintained in controlled environments.

25. Dependency or Sensitization Risk

Risk of abuse; monitoring recommended.

26. Long-Term Storage Recommendations

Store in dark, dry, cool places to prevent degradation.

27. Alternative Therapeutic Agents

R-Ketamine (arketamine), racemic ketamine.