Buy DXM Freebase (Dextromethorphan Freebase) – USA & Europe

1. What is DXM Freebase?

DXM Freebase refers to the unbound, neutral base form of dextromethorphan, a widely used cough suppressant and dissociative agent. Unlike its hydrobromide salt form, the freebase is less water-soluble but is often used in research contexts for its pharmacological properties or for formulation in different delivery systems.

2. Chemical Composition & Structure

Dextromethorphan Freebase has the molecular formula C18H25NO and a molar mass of 271.4 g/mol. It is a morphinan derivative with a 3-methoxy and 17-methyl substitution and is closely related structurally to opioid compounds without typical opioid activity. The freebase is an odorless crystalline white or yellowish powder, freely soluble in organic solvents such as chloroform but poorly soluble in water.

3. Research Applications

DXM Freebase is studied for its role as a non-competitive NMDA receptor antagonist and sigma-1 receptor agonist. Research investigates its neuroprotective, analgesic, dissociative, and antidepressant effects. The freebase form allows for specialized preparation and pharmacokinetics assessment in various experimental setups.

4. Recommended Laboratory Handling & Safety Guidelines

Handle with appropriate personal protective equipment including gloves and eye protection. Use in well-ventilated areas or fume hoods to avoid inhalation. Store in tightly sealed containers away from moisture and light to maintain stability.

5. Hazard Warnings & Risk Statements

Classified as harmful if swallowed or inhaled and may cause skin and eye irritation (GHS07). Avoid exposure through direct contact, inhalation, or ingestion. Follow safety data sheet instructions rigorously.

6. Compatibility with Other Chemicals

Soluble in ethanol, chloroform, and other organic solvents; sparingly soluble in water. Avoid strong oxidizers or reactive chemicals.

7. Emergency Protocols for Exposure

In case of skin or eye contact, flush with plenty of water. If inhaled or ingested accidentally, seek immediate medical intervention.

8. Storage Stability & Shelf Life

Store in cool, dry, and dark conditions below room temperature. Use airtight containers to prevent degradation and moisture ingress.

9. Licensing & Purchase

Available for research use where legally permitted. Confirm licensing and regulations before procurement.

10. Legality of Online Purchase

Legal status varies by jurisdiction; buyers must ensure compliance with local laws.

11. Laboratory Safety Practices

Use appropriate PPE, controlled environment, and proper disposal protocols.

12. Medical Considerations

Avoid exposure during pregnancy or in individuals with respiratory or neurological conditions.

13. Potential Allergic Reactions

Minimal but wear gloves to prevent contact dermatitis.

14. Interactions with Other Research Chemicals

Potential CNS interaction with serotonergic, opioid, or dissociative agents; caution and documentation advised.

15. Pregnancy Precautions

Not recommended.

16. Handling for Consistency

Use precise weighing instruments and follow storage protocols for reproducibility.

17. Optimizing Research Outcomes

Employ high-purity samples and validated analytic methods.

18. Reported Pharmacological Effects

Acts as a cough suppressant, dissociative, neuroprotective, NMDA antagonist, and sigma-1 receptor agonist.

19. Known Adverse Effects

Reactions may include dizziness, nausea, hallucinations, and at higher doses, dissociation.

20. Severe Exposure Responses

Medical assistance required for overdose or adverse events.

21. Solvent Use

Dissolves readily in organic solvents such as ethanol and chloroform.

22. Research Timing Importance

Maintaining dosing schedule enhances study outcomes.

23. Recommended Storage Duration

Stable for years under ideal storage.

24. Post-Research Stability

Proper storage extends shelf life; dispose of any degraded samples appropriately.

25. Dependency or Sensitization Risk

Low risk of addiction but psychological dependence potential exists.

26. Long-Term Storage Recommendations

Seal in an airtight container under inert atmosphere when possible; store cool and dry.

27. Alternative Research Molecules

Other NMDA antagonists include ketamine, memantine, and phencyclidine.