Buy DXM HBr (Dextromethorphan Hydrobromide) – USA & Europe

1. What is DXM HBr?

DXM HBr, or Dextromethorphan Hydrobromide, is a white crystalline or powder form of the cough suppressant dextromethorphan combined with hydrobromide salt to improve stability and solubility. It is widely used as an antitussive agent in over-the-counter cough medicines but also has research applications due to its unique pharmacological effects.

2. Chemical Composition & Structure

Dextromethorphan hydrobromide has the molecular formula C18H26BrNO with a molecular weight of approximately 352.31 g/mol. Chemically, it is 3-methoxy-17-methyl-9α,13α,14α-morphinan hydrobromide monohydrate. Its structure features a morphinan backbone related to opioids but without typical opioid activity.

3. Research Applications

DXM HBr is studied for its action as a non-competitive NMDA receptor antagonist and sigma-1 receptor agonist. Research investigates its neuroprotective, analgesic, and dissociative effects, as well as potential for treating neuropathic pain and mood disorders.

4. Recommended Laboratory Handling & Safety Guidelines

Handle using gloves and eye protection in a well-ventilated area. Avoid inhalation, ingestion, and skin contact. Store in a cool, dry place in tightly sealed containers to maintain stability.

5. Hazard Warnings & Risk Statements

Classified as harmful (GHS07) with hazard statements indicating toxicity if swallowed and irritation on contact. Use appropriate safety protocols to avoid accidental exposure.

6. Compatibility with Other Substances

Soluble in ethanol and sparingly soluble in water. Avoid mixing with strong oxidizing agents or incompatible chemicals.

7. Emergency Protocols for Exposure

In case of ingestion, seek immediate medical attention. Skin or eye contact requires thorough rinsing. Inhalation should be managed by moving to fresh air and medical evaluation if symptoms persist.

8. Storage Stability & Shelf Life

Store protected from moisture and light, preferably below room temperature, to preserve chemical integrity and potency for extended periods.

9. Licensing & Purchase

Available for research purchase in compliance with local regulations. Confirm legal status before acquisition.

10. Legality of Online Purchase

Widely legal as pharmaceutical raw material; controlled in some jurisdictions.

11. Laboratory Safety

Comply with all chemical safety guidelines, including PPE and proper waste disposal.

12. Special Medical Considerations

Avoid exposure if pregnant or suffering from respiratory or neurological disorders.

13. Allergen Exposure Risk

Minimal but handle carefully to prevent irritation.

14. Use with Other Research Chemicals

Carefully assess potential interactions, especially with CNS-active substances.

15. Pregnancy Precautions

Not recommended during pregnancy.

16. Proper Handling for Consistency

Use precise weighing and storage protocols.

17. Optimizing Research Results

Use high-purity grades (>98%) and validated assay methods.

18. Reported Effects & Efficacy

Exerts antitussive, dissociative, analgesic, and neuroprotective effects largely via NMDA antagonism.

19. Known Adverse Effects

Adverse reactions include dizziness, nausea, and occasional hallucinations at high doses.

20. Severe Exposure Management

Immediate medical intervention required in cases of overdose or severe toxicity.

21. Alcohol Solvent Use

Freely soluble in ethanol; sparingly soluble in water.

22. Research Scheduling

Adherence to dosing schedules ensures reproducible outcomes.

23. Recommended Storage Duration

Stable for several years under ideal conditions.

24. Stability After Testing

Maintain samples in original containers; dispose of unused material per hazardous waste protocols.

25. Risk of Dependency or Sensitization

Minimal abuse potential but caution warranted.

26. Long-Term Storage Recommendations

Store in sealed containers away from light, moisture, and heat.

27. Alternative Research Chemicals

Other NMDA antagonists include ketamine and memantine.