Ketamine & Esketamine
Introduction: Why Choose Ketamine & Esketamine at Psychedelics Lab?
Ketamine and its enantiomer esketamine are dissociative anesthetics widely used not only for anesthesia but increasingly for psychiatric research and treatment, including depression. Psychedelics Lab provides pharmaceutical-grade ketamine and esketamine with purity exceeding 98%, manufactured under rigorous controls for advanced research in the USA and Europe. These compounds are valuable tools in neuropharmacology, psychiatry, and neuroscience studies due to their unique pharmacological profiles.
What Are Ketamine and Esketamine?
Ketamine is a chiral compound comprising two enantiomers: (S)-ketamine (esketamine) and (R)-ketamine (arketamine). Esketamine, the S-enantiomer, has a higher affinity for NMDA receptors and is generally more potent, explaining its targeted use as an antidepressant nasal spray approved by the FDA (Spravato®). Racemic ketamine contains an equal mixture of both enantiomers and is commonly administered intravenously or intramuscularly for anesthesia and off-label depression treatment. Both act primarily as NMDA receptor antagonists, with additional effects on opioid, cholinergic, and monoaminergic systems.
Popular Ketamine & Esketamine Research Chemicals
| Product Name | Purity Level | CAS Number | Research Use Cases | Availability in USA/EU |
|---|---|---|---|---|
| Racemic Ketamine | ≥98% | 6740-88-1 | Anesthetic research, neuropharmacology | Available |
| Esketamine (S-Ketamine) | ≥98% | 72654-62-5 | Treatment-resistant depression studies | Available |
Both compounds are synthesized and purified with stringent quality controls and verified by advanced methods such as HPLC and mass spectrometry.
Why Purity Matters: Psychedelics Lab Standard
The high potency and narrow therapeutic window of ketamine and esketamine necessitate purity above 98% to avoid adverse effects and ensure reproducible research outcomes. Psychedelics Lab utilizes validated synthesis and analytical protocols with third-party certifications. Certificates of Analysis accompany every batch, supporting scientific transparency and confidence.
FAQ: How Is Purity Determined?
Purity assessments are conducted using chromatographic techniques with UV and mass spectrometric detection, ensuring precise quantification and consistency.
Safety, Compliance, and Delivery
Ketamine and esketamine are distributed for research purposes conforming to USA and European regulations, with explicit disclaimers about their legal status and purchase conditions. Safe, discreet shipping with insurance and tracking is standard. Recommended storage is cool, dark, and dry to maintain chemical stability.
How to Choose Ketamine or Esketamine for Research
Esketamine offers higher potency and more selective NMDA receptor antagonism, useful for depression and sensory modulation studies, often administered as a nasal spray. Racemic ketamine is versatile for anesthesia, analgesia, and off-label psychiatric research, typically used intravenously or intramuscularly. Selection depends on research goals, administration feasibility, and desired pharmacokinetic profiles. Psychedelics Lab supports researchers with in-depth consultation services.
Frequently Asked Questions
What is the main difference between ketamine and esketamine?
Esketamine is the S-enantiomer of ketamine with greater NMDA receptor affinity and clinical approval for treatment-resistant depression, while ketamine is a racemic mixture.
Are there regulatory restrictions on purchase?
Ketamine and esketamine are provided for research use with purchaser responsibility for local legal compliance.
Is technical and scientific support available?
Yes, Psychedelics Lab provides expert guidance.
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